It has been shown to help people with anxiety and sleep disorders and has far fewer side effects than most prescription drugs. A clear relationship between the symptoms of Tourette’s syndrome and the sites or mechanisms of action of cannabinoids has not been established. However, case reports suggest that cannabis may reduce tics and that the therapeutic effects of cannabis may be due to the anxiety-reducing properties of marijuana and not to a specific anti-tic effect (Hemming and Yellowlees, 1993; Sandyk and Awerbuch, 1988). Two small studies provide limited evidence of the therapeutic effects of THC capsules on the severity of TIC and overall clinical outcomes.
The researchers reported that dronabinol was very well tolerated and postulated that the dose of dronabinol may have been too low, in addition to suggesting that a knock-on effect in the crossover design may have obscured differences in the treatment groups. CBD oil is widely regarded as an effective product for the treatment and control of pain. The endocannabinoid system is a specialized system in the human body that helps regulate sleep, appetite, immune system and pain response. These naturally produced endocannabinoids are neurotransmitters that bind to the cannabinoid receptors of the body’s nervous system. CBD can help relieve chronic pain by affecting the activity of this receptor, thereby reducing inflammation and interacting with neurotransmitters. Research is currently underway to what extent CBD can help with diseases such as arthritis and multiple sclerosis.
Finally, a review (Andreae et al., 2015) conducted a Bayesian analysis of five primary peripheral neuropathy studies that had tested the efficacy of flower-shaped cannabis administered by inhalation. Two of the primary studies in this review were also included in the Whiting Review, the other three were not. It is worth noting that the conclusions of all the reviews largely coincided, which suggests that cannabinoids have a modest effect on pain. For the purposes of this discussion, the main source of information on the effect of cannabinoids on chronic pain was the review by Whiting et al. . RCTs comparing cannabinoids with usual treatment, placebo, or no treatment for 10 conditions were included. If RCTs were not available for a disease or outcome, non-randomized trials, including uncontrolled trials, were considered.
The mean reduction in motor seizures while taking cannabidiol was 36.5 percent in this uncontrolled case series (IQR 0-64.7). A single small study found no effect of two doses of dronabinol on gastrointestinal transit. The quality of the evidence for the finding that no effect was detected in irritable bowel syndrome is insufficient due to the short duration of treatment, the small sample size, the short-term follow-up and the absence of patient-reported results. Studies evaluating the effects of cannabinoids on patient-reported outcomes are needed to better understand the clinical implications in patients with IBS.
Of the states that provide some access to cannabis compounds, cancer, HIV / AIDS, multiple sclerosis, glaucoma, seizures / epilepsy and pain are among the most recognized qualified diseases (Belendiuk et al., 2015; NCSL, 2016). There are certain states that offer more flexibility than others and that allow the use of medical cannabis to treat diseases in which the drug relieves the individual. Given the constant liberalization of cannabis laws, the number of these states is likely to increase, and therefore support efforts to clarify the possible therapeutic benefits of medical cannabis for various health outcomes. Systematic reviews of good quality identified only two small studies with an uncertain to high risk of bias in which cannabinoids were investigated for the treatment of schizophrenia. These studies provide limited evidence due to the risk of bias, short-term follow-up and evaluation of a single cannabinoid.
Randomized studies on the effectiveness of cannabidiol in various forms of epilepsy have been completed,7 but their results have not been published at the time of this report. CBD can help with Green Roads CBD Review nausea, vomiting and weight loss caused by chemotherapy treatments. The FDA has approved three cannabis products to alleviate these symptoms and increase the appetite of people with AIDS.